Biochemical Changes in a Chemically Defined Medium by Submerged Cultures of <i>Streptomyces erythreus</i>

Abstract

A chemically defined medium is an important aid in the study of the synthesis of antibiotics by microorgan- isms.It affords a minimum of interference from ill- defined substances and the effects of various nutrients may be studied more effectively.The synthesis of erythromycin by Streptomyces ery- threus was studied with a chemically defined medium.This report discusses some of the metabolic changes observed during the fermentation.These changes in- clude growth, antibiotic production, hydrogen-ion con- centration, and carbohydrate and nitrogen utilization.The development of the chemically defined medium will be discussed in a separate paper.