PubMed · 2008 · 18 citations · 5 references
MedicineDermatologyPharmacotherapyCutaneous OncologyDermatopathologyRheumatologyDrug-induced Skin ReactionsOral Mucosal LesionsPsoriatic ArthritisDrug-induced Mucocutaneous ReactionsDrug-induced Oral UlcerationDrug-induced Oral UlcersDrug-induced Skin EruptionsMedication-induced Oral UlcerationMedication-related Oral UlcerationPsoriasis TherapyPsoriatic Disease
Although methotrexate (MTX) is used in several medical specialties including dermatology, rheumatology, and oncology, drug-induced mucocutaneous ulcerations rarely are reported. We present a 36-year-old woman with plaque psoriasis and psoriatic arthritis being treated with oral MTX (12.5 mg weekly) and oral methoxsalen plus UVA. Following an increase in MTX dose, she developed erosions and ulcerations on her oral mucosa and within her psoriatic plaques. All erosions and ulcerations healed within 2 weeks upon discontinuation of MTX.
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Cutaneous ulceration caused by methotrexate
Dana W Kazlow, David Federgrun, Stephen B. Kurtin et al. · Journal of the American Academy of Dermatology · 2003 · 55 citations
Methotrexate-induced necrolysis
Kenneth M. Reed, Arthur J. Sober · Journal of the American Academy of Dermatology · 1983 · 47 citations