Aging Affects the Association Between Endothelial Nitric Oxide Synthase Gene Polymorphism andAcute Myocardial Infarction in the Korean Male Population

Abstract

Our work provides the first evidence that links ecNOS polymorphism to the risk of AMI in relation to age. Young persons who smoke or have ecNOSaa genotype may have an increased risk of developing AMI. The functional as well as structural changes associated with aging in the vascular endothelium may mask the effect of the ecNOS polymorphism in the development of AMI in old persons.