Ichthyosis vulgaris. A clinical and histopathological study of patients and their close relatives in the autosomal dominant and sex-linked forms of the disease.

Abstract

The effect of occlusion on epidermal morphology was studied at electron microscopic resolution. the morphological changes recorded were relatively mild, though conspicuous, and consisted in dilatation of the intercellular space, appearance of cytoplasmic vacuoles and an oedematous change in the dermis. Stereological analysis showed that the dilatation of the intercellular space had a biphasic time-dependent course. Dansyl chloride applied under occlusion was shown to cause the same type of changes as did simple occlusion, but the changes appeared earlier.