Concepedia

Healing of rat femoral segmental defect with bone morphogenetic protein-2: a dose response study.

Siddhesh R. Angle, Kotaro Sena, Dale R. Sumner, Walter W. Virkus, Amarjit S. Virdi

PubMed · 2012 · 42 citations · 21 references

Abstract

Our findings revealed that all doses of rhBMP-2 result in new bone formation. However, there is an optimum dose of 12 μg of rhBMP-2 for bone repair in this model, above which and below which less stimulation of bone occurs.

References

21

Bone: Formation by Autoinduction

Marshall R. Urist · Science · 1965 · 5.5K citations

, , +14

Novel Regulators of Bone Formation: Molecular Clones and Activities

John M. Wozney, Vicki Rosen, Anthony Celeste et al. · Science · 1988 · 3.9K citations

Complications of Iliac Crest Bone Graft Harvesting

Edward D. Arrington, William J. Smith, Henry G. Chambers et al. · Clinical Orthopaedics and Related Research · 1996 · 1.5K citations

, , +12

The Cell and Molecular Biology of Fracture Healing

Thomas A. Einhorn · Clinical Orthopaedics and Related Research · 1998 · 1.3K citations

, , +16

OSTEOGENIC ACTIVITY OF THE FOURTEEN TYPES OF HUMAN BONE MORPHOGENETIC PROTEINS (BMPS)

Hongwei Cheng, Wei Jiang, Frank M. Phillips et al. · Journal of Bone and Joint Surgery · 2003 · 1K citations