FK 506 as a growth control factor.

Abstract

In doing liver transplantation, it is important to know the effect of immunosuppressive agents on hepatic regeneration. In many such patients, livers are transplanted that are not the ideal size for a particular recipient. Accommodation of these organs to recipient size depends on poorly understood growth homeostasis which conceivably could be altered by the immunosuppressive agents. In fact, it has been reported that the regeneration response is inhibited by azathioprine and adrenal cortical steroids. 1,2