American Journal of Tropical Medicine and Hygiene · 1988 · 84 citations · 0 references
Veterinary MedicineInfectious DiseasesVeterinary MicrobiologyMolecular VirologyVirologyAnimal Infectious DiseasesAnimal VirusesRodent Infectious DiseasesViral InfectionsViral ZoonosesZoonotic VirusesAerosol Transmission ExposureHantavirus InfectionsInfectious Dose EstimationInoculationPlaque QuantificationRodent-borne Viral DiseasesRodent-borne Viral ZoonosesRodent-borne Zoonoses
Hantaan, Seoul, and Puumala viruses were transmitted to 12-16-week-old female Wistar Rattus norvegicus by inhalation. The rodent infectious dose for each virus by intramuscular inoculation and by inhalation was determined, as was the infectious dose for Vero E-6 cells by direct plaque assay.