Drug points: Agranulocytosis associated with lamotrigine

Abstract

To our knowledge, only leucopenia and thrombocytopenia have been described as possible haematological side effects of lamotrigine.1–3 We report a case of agranulocytosis associated with lamotrigine treatment. A white girl aged 11 years 10 months who had left renal agenesis, an imperforate anus (corrected postnatally), neuronal heterotopia at the left insula, and seizures had been free of seizures for nearly two years while taking carbamazepine. …