Current Science · 2006 · 33 citations · 0 references
Life SciencesInfectious DiseasesAntimicrobial ResistanceInfection PreventionMedical MicrobiologyAntibacterial ResistanceAntibiotic ResistanceAntimicrobial Susceptibility TestingCombination Antimicrobial TherapyDrug Interactions With AntimicrobialsAntibacterial Susceptibility TestingAntibiotic CombinationsAntibiotic Susceptibility TestingBactericidal AgentsCombination Antibiotic TestingCombination Therapy EvaluationMinimum Inhibitory Concentration TestingSynergistic Drug Combinations
The recent increase in the incidence of infections due to bacterial resistance to antibiotics has been recognized as an alarming problem, especially in the hospital environment with probability of cross-infection. Silver-Water Dispersion® ΤΜ solution as an antibacterial is claimed to have no bacterial resistance. Nineteen antibiotics were checked in combination with Silver-Water Dispersion ΤΜ solution against seven microbial organisms for synergism. First, minimal inhibitory concentrations were determined for the individual antibiotics and Silver-Water Dispersion ΤΜ solution individually. Those combinations of individual antibiotics with Silver-Water Dispersion ΤΜ that displayed synergism were further evaluated through the checkerboard method. Synergistic activity of Silver-Water Dispersion ΤΜ solution in combination with nineteen antibiotics was tested against seven bacterial strains, except where an organism was known to be resistant to the antibiotic. Out of 96 tests, five were synergistic, 89 additive, and two antagonistic.