Experimental Renal Erythrocytosis. I. Effects of Pressure and Vascular Interference

Abstract

Abstract Experimental data presented in this study indicate that prolonged pressure exerted on the kidneys of rabbits may lead to true erythrocytosis. With approximately 60 per cent of rabbits developing erythrocytosis, the pressure of experimentally induced unilateral hydronephrosis appears to be most effective in this respect. It is suggested that of the role of the renal medulla in the production of erythrocytosis is an important one. Interference with renal arteries and veins did not result in erythrocytosis. The role of erythropoietin and the possible mechanisms by which "renal pressure erythrocytosis" is produced is discussed.