Layered Double Hydroxide Assemblies with Controllable Drug Loading Capacity and Release Behavior as well as Stabilized Layer-by-Layer Polymer Multilayers

Abstract

A stable drug release system with magnetic targeting is essential in a drug delivery system. In the present work, layered double hydroxide assemblies stabilized by layer-by-layer polymer multilayers were prepared by alternative deposition of poly(allylamine hydrochloride) and poly(acrylic acid) species on composite particles of Fe3O4 and ZnAl-LDH and then covalent cross-linkage of the polymer multilayers by photosensitive cross-linker. The successful fabrication was recorded by Zeta potential and Fourier transform infrared spectrum measurements. The formed assemblies were stable in high pH solutions (pH > 7). The drug loading capacity and release behavior of the assemblies could be controlled by treatment with appropriate acidic solution, and were confirmed by loading and release of a simulated drug, methylene blue. The formed assemblies possessed enough saturated magnetic strength and were sensitive to external magnetic field which was essential for targeting drug delivery. The formed assemblies were multifunctional assemblies with great potential as drug delivery system.