Computed Tomography Imaging of Transferrin Targeting Liposomes Encapsulating Both Boron and Iodine Contrast Agents by Convection-Enhanced Delivery to F98 Rat Glioma for Boron Neutron Capture Therapy

Abstract

The combination of TF-PEG liposome encapsulating sodium borocaptate and Iomeprol and intratumoral CED enables not only a precise and potent targeting of boron delivery to the tumor tissue, but also the ability to follow the trace of boron delivery administered intratumorally by real-time computed tomography.