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The pallid mouse. A model of genetic alpha 1-antitrypsin deficiency.

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Citations

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References

1993

Year

Piero A. Martorana, Theodor von Brand, Concetta Gardi, P Even, M. M. De Santi, P. Calzoni, Paola Marcolongo, Giuseppe Lungarella
PubMed

Abstract

All these data suggest that the lung changes in pallid mice are the result of an elastolytic process due to a severe inborn deficiency of serum alpha 1-antitrypsin. This animal model reproduces important features of the human condition and may provide new insights into the pathogenesis of emphysema.