Suppression of growth and transformation and induction of apoptosis by EGR-1.

Abstract

Although cloned as an "immediate-early gene," recent studies show that EGR-1 functions in growth regulation and suppression of transformation by transactivation of the transforming growth factor beta-1 (TGF-beta1) gene and cooperation with Sp1, Jun-B, p21WAF1/Cip1, and stimulates apoptosis by transactivation of the p53 gene.