Physiology · 1988 · 13 citations · 0 references
MedicineBiochemistryPhysiologyCalcium HomeostasisMineral MetabolismRenal PathophysiologyCalcium MetabolismCalcium SignalingCalcium Transport ProteinsRenal Calcium HandlingRenal Mineral HandlingBasolateral MembraneCalcium AtpaseCalcium PumpsCalcium TransportDistal Tubular Calcium TransportDistal Tubule PhysiologyRenal Calcium ExchangeRenal Calcium Transport Physiology
Epitopes of the calmodulin-sensitive erythrocyte Ca2+-Mg2+-ATPase enzyme were found exclusively in basolateral membranes of distal tubule cells of the human and rat kidney;other kidney segments did not contain this enzyme in detectable amounts. The calmodulin-sensitive Ca2+-Mg2+-ATPase acts as a calcium pump in the red cell and other tissues. Its presence in the kidney distal tubule, a site where hormone-sensitive calcium transport is known to occur, raises the possibility that this enzyme may act as a hormone-regulated pump in this nephron segment.