Southern Medical Journal · 1983 · 28 citations · 0 references
PharmacyPharmacologyPharmacotherapyHepatologyHepatotoxicologyHypersensitivityHepatic ImpairmentHepatic ToxicityLiver DiseaseCarbamazepine PharmacologyDrug-induced Hepatic NecrosisDrug-induced Liver Injury AssessmentGranulomatous HepatitisGranulomatous Liver DiseaseHepatocellular Liver InjuryHistologic ExaminationInflammatory Liver Injury
Two patients had carbamazepine-induced liver injury. The clinical, biochemical, and histologic data suggest hepatitis of the idiosyncratic hypersensitivity type with granulomas in one patient; in the other, the liver injury resembles that caused by a hepatotoxin. Both patients showed prompt recovery upon discontinuation of the drug.