Studies on Ketosis: I. The Relation between Alkalosis and Ketosis

Abstract

THE appearance of acetone bodies in the urine (ketosis) occurs in man in many diverse conditions, and is usually associated with an upset in the metabolism of carbohydrate or with damage to the liver function. Davies, Haldane and Kennaway [1920] found that ketone bodies appear in small concentrations in the urine during experimental alkalosis; and it has recently been shown by Haldane, Wigglesworth and Woodrow [1924] that concurrently with this acetonuria there is a considerable disturbance of the normal meta- bolism of carbohydrate. The main object of the present work was to determine the relation between the ketosis of carbobydrate inanition and the acetonuria induced by alkalosis.