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Functional characterization of somatic mutations in cancer using network-based inference of protein activity

Mariano J. Alvarez, Yao Shen, Federico M. Giorgi et al. · Nature Genetics · 2016 · 1K citations · Full text

Functional Genomics, Somatic Mutations, Somatic Variant +15

Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state

Gloria V. Echeverria, Zhongqi Ge, Sahil Seth et al. · Science Translational Medicine · 2019 · 298 citations

A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors

Mariano J. Alvarez, Prem S. Subramaniam, Laura H. Tang et al. · Nature Genetics · 2018 · 219 citations · Full text

Glioma, Medicine, Pharmacology +10

Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer

Tyler Risom, Ellen M. Langer, Margaret P. Chapman et al. · Nature Communications · 2018 · 177 citations · Full text

A modular master regulator landscape controls cancer transcriptional identity

Evan Paull, Àlvaro Aytés, Sunny J. Jones et al. · Cell · 2021 · 137 citations · Full text

Transcriptional Regulation, Transcription Regulation, Cancer Genomics +5