Network epigenetics is a research field that investigates the complex interplay between epigenetic modifications and the structure, dynamics, and function of biological networks. It seeks to understand how epigenetic changes influence and are influenced by the connectivity and overall behavior of molecular systems. This concept examines how specific epigenetic marks (e.g., DNA methylation, histone modifications, non-coding RNAs) affect the organization, signaling, and regulatory activity within cellular networks, such as gene regulatory networks, protein-protein interaction networks, and metabolic pathways. Key characteristics include a systems-level perspective, integration of multi-omics data (genomics, epigenomics, transcriptomics, proteomics), and computational modeling approaches to uncover network-level consequences of epigenetic alterations. Its significance lies in providing a holistic framework to understand complex biological phenomena, including development, cellular differentiation, disease pathogenesis (e.g., cancer, neurodevelopmental disorders), and environmental responses, by revealing how epigenetic information is processed and propagates through interconnected molecular components, thereby identifying potential network-based therapeutic targets.