Healthcare regionalization is a research concept and organizational framework investigating the division of a healthcare system into distinct geographical areas for the planning, administration, and delivery of health services. This academic concept analyzes how the delineation of regions, often with varying levels of service capacity and specialization, impacts resource allocation, service accessibility, efficiency, equity, and population health outcomes. Its significance lies in providing a structured approach to optimize healthcare system performance by aligning service provision with regional needs and facilitating coordinated care pathways within defined geographical boundaries.