A Phase I Study of Telomerase-specific Replication Competent Oncolytic Adenovirus (Telomelysin) for Various Solid Tumors

John Nemunaitis, Alex W. Tong, Michael Nemunaitis, +12

Molecular Therapy

Coxsackievirus B3 Is an Oncolytic Virus with Immunostimulatory Properties That Is Active against Lung Adenocarcinoma

Shohei Miyamoto, Hiroyuki Inoue, Takafumi Nakamura, +10

Cancer Research

In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus

Hiroyuki Kishimoto, Toru Kojima, Yuichi Watanabe, +10

Nature Medicine

Cancer ResearchTelomerase-specific Replication-selective AdenovirusVivo ImagingOncologic ImagingMedicine +8

In vivo internal tumor illumination by telomerase-dependent adenoviral GFP for precise surgical navigation

Hiroyuki Kishimoto, Ming Zhao, Katsuhiro Hayashi, +5

Proceedings of the National Academy of Sciences

A simple biological imaging system for detecting viable human circulating tumor cells

Toru Kojima, Yuuri Hashimoto, Yuichi Watanabe, +9

Journal of Clinical Investigation

EngineeringOncologic ImagingViral DiagnosticsImmunologyBlood Cell +22

Enhanced oncolysis by a tropism-modified telomerase-specific replication-selective adenoviral agent OBP-405 (‘Telomelysin-RGD’)

Masaki Taki, Shunsuke Kagawa, Masahiko Nishizaki, +7

Oncogene

Tumor Biology‘ Telomelysin-rgd ’Radiation OncologyMedicineCell Biology +3

Telomerase-Dependent Oncolytic Adenovirus Sensitizes Human Cancer Cells to Ionizing Radiation via Inhibition of DNA Repair Machinery

Shinji Kuroda, Toshiya Fujiwara, Yasuhiro Shirakawa, +10

Cancer Research

Tumor BiologyGenome InstabilityDna Double-strand BreaksRadiation TherapyOncogenic Agent +11

Immune Modulation by Telomerase-Specific Oncolytic Adenovirus Synergistically Enhances Antitumor Efficacy with Anti-PD1 Antibody

Nobuhiko Kanaya, Shinji Kuroda, Yoshihiko Kakiuchi, +13

Molecular Therapy

A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem–like Cells in S/G2/M Phases

Shuya Yano, Hiroshi Tazawa, Yuuri Hashimoto, +10

Clinical Cancer Research

Tumor-selective, adenoviral-mediated GFP genetic labeling of human cancer in the live mouse reports future recurrence after resection

Hiroyuki Kishimoto, Ryoichi Aki, Yasuo Urata, +5

Cell Cycle

Surgical OncologyEngineeringOncologic ImagingPathologyFluorescence Visualization +15