Hirotoshi Takahashi

Proteasome inhibitors can alter the signaling pathways and attenuate the P-glycoprotein-mediated multidrug resistance

Takeo Fujita, Kazuhiro Washio, Daisuke Takabatake et al. · International Journal of Cancer · 2005 · 60 citations · Full text

Tumor inhibitory effect of gefitinib (ZD1839, Iressa) and taxane combination therapy in EGFR‐overexpressing breast cancer cell lines (MCF7/ADR, MDA‐MB‐231)

Daisuke Takabatake, Takeo Fujita, Tadahiko Shien et al. · International Journal of Cancer · 2006 · 51 citations · Full text

Breast Oncology, Oncology, Medicine +15

Antitumor effect of gefitinib (‘Iressa’) on esophageal squamous cell carcinoma cell lines in vitro and in vivo

Fumikata Hara, Motoi Aoe, Hiroyoshi Doihara et al. · Cancer Letters · 2005 · 47 citations

Esophageal Cancer, Medicine, Cancer Cell Biology +9

Proteasome inhibitor bortezomib increases PTEN expression and enhances trastuzumab-induced growth inhibition in trastuzumab-resistant cells

Takeo Fujita, Hiroyoshi Doihara, Kazuhiro Washio et al. · Anti-Cancer Drugs · 2006 · 41 citations

Breast Oncology, Immunology, Cell Death +18

PLC and PI3K Pathways are Important in the Inhibition of EGF-lnduced Cell Migration by Gefitinib (‘lressa’, ZD1839)

Tadahiko Shien, Hiroyoshi Doihara, Humikata Hara et al. · Breast Cancer · 2004 · 33 citations

Signal Transduction, Developmental Biology, Pi3k Pathways +8