A macromolecular approach to eradicate multidrug resistant bacterial infections while mitigating drug resistance onset

Willy Chin, Guansheng Zhong, Qinqin Pu, +16

Nature Communications

miR-27b-3p inhibits proliferation and potentially reverses multi-chemoresistance by targeting CBLB/GRB2 in breast cancer cells

Danni Chen, Wengong Si, Jiaying Shen, +9

Cell Death and Disease

Highly potent antimicrobial polyionenes with rapid killing kinetics, skin biocompatibility and in vivo bactericidal activity

Shaoqiong Liu, Robert J. Ono, Hong Wu, +21

Biomaterials

Polymer-drug ConjugateSkin BiocompatibilityVivo Bactericidal ActivityAntimicrobial CompoundPharmacology

A miR-20a/MAPK1/c-Myc regulatory feedback loop regulates breast carcinogenesis and chemoresistance

Wengong Si, Jiaying Shen, Chengyong Du, +11

Cell Death and Differentiation

Breast Cancer GrowthBreast OncologyBreast Cancer TissuesCancer BiologyTumor Biology +15

Identification of invasion-metastasis-associated microRNAs in hepatocellular carcinoma based on bioinformatic analysis and experimental validation

Weiyang Lou, Jing Chen, Bisha Ding, +7

Journal of Translational Medicine

Exploring specific prognostic biomarkers in triple-negative breast cancer

Chang Bao, Yunkun Lu, Jishun Chen, +5

Cell Death and Disease

Polymers with distinctive anticancer mechanism that kills MDR cancer cells and inhibits tumor metastasis

Guansheng Zhong, Chuan Yang, Shaoqiong Liu, +15

Biomaterials

Tumor BiologyPolymer ChemistryDrug TargetingEngineeringInhibits Tumor Metastasis +12

Shikonin inhibits migration and invasion of triple-negative breast cancer cells by suppressing epithelial-mesenchymal transition via miR-17-5p/PTEN/Akt pathway

Chang Bao, Tao Liu, Ling-Bo Qian, +6

Journal of Cancer

Short Synthetic β‐Sheet Antimicrobial Peptides for the Treatment of Multidrug‐Resistant <i>Pseudomonas aeruginosa</i> Burn Wound Infections

Guansheng Zhong, Junchi Cheng, Zhen Liang, +7

Advanced Healthcare Materials

Peptide SciencePeptide TherapeuticsAntimicrobial ChemotherapyBacterial PathogensDrug Resistance +17

Degradable antimicrobial polycarbonates with unexpected activity and selectivity for treating multidrug-resistant Klebsiella pneumoniae lung infection in mice

Chuan Yang, Weiyang Lou, Guansheng Zhong, +14

Acta Biomaterialia

Degradable Antimicrobial PolycarbonatesAntibioticsLung InflammationMedicineKlebsiella Pneumoniae +10