Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

Zobair M. Younossi, Vlad Ratziu, Rohit Loomba, +380

The Lancet

Interim AnalysisMetabolic Associated SteatohepatitisHepatologyPlacebo-controlled Phase 3Nonalcoholic Fatty Liver Disease +5

Treatment of HCV with ABT-450/r–Ombitasvir and Dasabuvir with Ribavirin

Jordan J. Feld, Kris V. Kowdley, Eoin Coakley, +9

New England Journal of Medicine

Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials

Stephen A. Harrison, Vincent Wai‐Sun Wong, Takeshi Okanoue, +632

Journal of Hepatology

FibrosisHepatologyLiver PhysiologyClinical TrialsPathology +7

Glecaprevir plus pibrentasvir for chronic hepatitis C virus genotype 1, 2, 4, 5, or 6 infection in adults with compensated cirrhosis (EXPEDITION-1): a single-arm, open-label, multicentre phase 3 trial

Xavier Forns, Samuel S. Lee, Joaquin Valdes, +16

The Lancet Infectious Diseases

HepatologyHepatitis CViral HepatitisLiver PhysiologyMulticentre Phase 3 +9

Glecaprevir and pibrentasvir yield high response rates in patients with HCV genotype 1–6 without cirrhosis

Paul Y. Kwo, Fred Poordad, Armen Asatryan, +19

Journal of Hepatology

Diagnostic VirologyHepatologyHepatitis CViral HepatitisImmunology +7

Efficacy and Safety of RBX2660 in PUNCH CD3, a Phase III, Randomized, Double-Blind, Placebo-Controlled Trial with a Bayesian Primary Analysis for the Prevention of Recurrent Clostridioides difficile Infection

Sahil Khanna, Maha Assi, Christine Lee, +12

Drugs

Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: a mechanism of UDCA cytoprotection.

Ravi Botla, James R. Spivey, Humberto Aguilar, +2

Journal of Pharmacology and Experimental Therapeutics

Efficacy of Glecaprevir/Pibrentasvir for 8 or 12 Weeks in Patients With Hepatitis C Virus Genotype 2, 4, 5, or 6 Infection Without Cirrhosis

Tarik Asselah, Kris V. Kowdley, Neddie Zadeikis, +19

Clinical Gastroenterology and Hepatology

Risk of colorectal neoplasia in patients with primary sclerosing cholangitis and ulcerative colitis following orthotopic liver transplantation

Edward V. Loftus, Humberto Aguilar, William J. Sandborn, +5

Hepatology

Surgical OncologyPosttransplantation ExperienceColorectal SurgeryGastroenterologyPathology +14

Next-Generation Multitarget Stool DNA Test for Colorectal Cancer Screening

Thomas F. Imperiale, Kyle Porter, Julia Zella, +10

New England Journal of Medicine