Organoid Modeling of the Tumor Immune Microenvironment

James T. Neal, Xingnan Li, Junjie Zhu, +31

Cell

Immune EvasionImmunologyTumor ImmunityOrganoid ModelingBiological Microenvironments +4

Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility

Sarah K. Denny, Dian Yang, Chen-Hua Chuang, +14

Cell

Tumor BiologyChromatinChromatin AccessibilityChromatin RemodelingMedicine +6

Comprehensive T cell repertoire characterization of non-small cell lung cancer

Alexandre Reuben, Jiexin Zhang, Shin-Heng Chiou, +55

Nature Communications

Molecular definition of a metastatic lung cancer state reveals a targetable CD109–Janus kinase–Stat axis

Chen-Hua Chuang, Peyton Greenside, Zoe Rogers, +15

Nature Medicine

OncologyMedicineImmune SurveillanceBronchial NeoplasmMolecular Definition +5

Global analysis of shared T cell specificities in human non-small cell lung cancer enables HLA inference and antigen discovery

Shin-Heng Chiou, Diane Tseng, Alexandre Reuben, +37

Immunity

Up-regulation of Inhibitory Natural Killer Receptors CD94/NKG2A with Suppressed Intracellular Perforin Expression of Tumor-Infiltrating CD8+ T Lymphocytes in Human Cervical Carcinoma

Bor‐Ching Sheu, Shin-Heng Chiou, Ho‐Hsiung Lin, +4

Cancer Research

Multiplexed in vivo homology-directed repair and tumor barcoding enables parallel quantification of Kras variant oncogenicity

Ian P. Winters, Shin-Heng Chiou, Nicole K. Paulk, +8

Nature Communications

BLIMP1 Induces Transient Metastatic Heterogeneity in Pancreatic Cancer

Shin-Heng Chiou, Viviana I. Risca, Gordon Wang, +14

Cancer Discovery

An in vivo multiplexed small-molecule screening platform

Barbara M. Grüner, Christopher J. Schulze, Dian Yang, +10

Nature Methods

EngineeringSingle-molecule DetectionBiomedical EngineeringMedicineMolecular Imaging +3

In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls

Wei Jiang, James R. Birtley, Shu-Chen Hung, +15

Nature Communications