Overexpression of <i>Osmyb4</i> enhances compatible solute accumulation and increases stress tolerance of <i>Arabidopsis thaliana</i>

Monica Mattana, Elisa Biazzi, Roberto Consonni, +4

Physiologia Plantarum

EngineeringGeneticsMolecular BiologyArabidopsis Transgenic PlantsMolecular Genetics +18

NMR quantification using an artificial signal

Roger D. Farrant, J. C. Hollerton, Sean M. Lynn, +3

Magnetic Resonance in Chemistry

Design, Synthesis, and Biological Evaluation of Novel Aminobisphosphonates Possessing an in Vivo Antitumor Activity Through a γδ-T Lymphocytes-Mediated Activation Mechanism

Daniele Simoni, Nicola Gebbia, Francesco Paolo Invidiata, +15

Journal of Medicinal Chemistry

Antitumor ActivityImmunologyPharmacotherapyImmunotherapyPharmaceutical Chemistry +14

Discovery Process and Pharmacological Characterization of 2-(<i>S</i>)-(4-Fluoro-2-methylphenyl)piperazine-1-carboxylic Acid [1-(<i>R</i>)-(3,5-Bis-trifluoromethylphenyl)ethyl]methylamide (Vestipitant) as a Potent, Selective, and Orally Active NK₁ Receptor Antagonist

Romano Di Fabio, Cristiana Griffante, Giuseppe Alvaro, +16

Journal of Medicinal Chemistry

Discovery and Biological Characterization of (2<i>R</i>,4<i>S</i>)-1′-Acetyl-<i>N</i>-{(1<i>R</i>)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-<i>N</i>-methyl-4,4′-bipiperidine-1-carboxamide as a New Potent and Selective Neurokinin 1 (NK₁) Receptor Antagonist Clinical Candidate

Romano Di Fabio, Giuseppe Alvaro, Cristiana Griffante, +14

Journal of Medicinal Chemistry

Synthesis and Pharmacological Characterization of Novel Druglike Corticotropin-Releasing Factor 1 Antagonists

Romano Di Fabio, Yves St‐Denis, Fabio Maria Sabbatini, +25

Journal of Medicinal Chemistry

Pharmacological CharacterizationNew CrfReceptor AntagonistsPharmacotherapyMolecular Pharmacology +14

Substituted Analogues of GV150526 as Potent Glycine Binding Site Antagonists in Animal Models of Cerebral Ischemia

Romano Di Fabio, Nadia Conti, Elisabetta De Magistris, +6

Journal of Medicinal Chemistry

PharmacotherapyCerebral Vascular RegulationMolecular PharmacologyMedicinal ChemistryAnimal Models +20

Cyclative cleavage via solid-phase supported stabilized sulfur ylides: synthesis of macrocyclic lactones

Elena La Porta, Umberto Piarulli, Francesca Cardullo, +4

Tetrahedron Letters

EngineeringHeterocyclicMacrocyclic LactonesCyclative CleavageStabilized Sulfur Ylides +6

Exploration of the Amine Terminus in a Novel Series of 1,2,4-Triazolo-3-yl-azabicyclo[3.1.0]hexanes as Selective Dopamine D₃Receptor Antagonists

Fabrizio Micheli, Luca Arista, Barbara Bertani, +14

Journal of Medicinal Chemistry

Application of the QbD Principles in the Development of the Casopitant Mesylate Manufacturing Process. Process Research Studies for the Definition of the Control Strategy of some Drug Substance-CQAs for Stages 2a, 2b, and 2c

Zadeo Cimarosti, Fernando Bravo, Damiano Castoldi, +5

Organic Process Research & Development

EngineeringIndustrial EngineeringProcess DevelopmentBiomedical EngineeringDrug Substance-cqas +15