Improved dissolution and pharmacokinetic behavior of cyclosporine A using high-energy amorphous solid dispersion approach

Satomi Onoue, Hideyuki Sato, Kumiko Ogawa, +5

International Journal of Pharmaceutics

Pharmaceutical ScienceMedicinePharmaceutical TechnologyCyclosporine APharmacokinetic Behavior +4

In vitro and in vivo characterization on amorphous solid dispersion of cyclosporine A for inhalation therapy

Satomi Onoue, Hideyuki Sato, Yohei Kawabata, +3

Journal of Controlled Release

Lung DepositionCyclosporine ABiomedical EngineeringPharmacologyAmorphous Solid Dispersion +1

Thymidylate synthase levels as a therapeutic and prognostic predictor in breast cancer.

Reiki Nishimura, Kenji Nagao, Haruhiko Miyayama, +9

PubMed

Tumor BiologyPrognostic PredictorTs LevelsOncologyBreast Oncology +13

Self-micellizing solid dispersion of cyclosporine A with improved dissolution and oral bioavailability

Satomi Onoue, Hiroki Suzuki, Yoshiki Kojo, +6

European Journal of Pharmaceutical Sciences

Pharmaceutical ScienceOral BioavailabilityMedicineCyclosporine ASelf-micellizing Solid Dispersion +4

Inhalable dry-emulsion formulation of cyclosporine A with improved anti-inflammatory effects in experimental asthma/COPD-model rats

Satomi Onoue, Hideyuki Sato, Kumiko Ogawa, +6

European Journal of Pharmaceutics and Biopharmaceutics

InflammationAsthmaExperimental Asthma/copd-model RatsAnti-inflammatoryInflammatory Lung Disease +9

Liposomal formulations of glucagon-like peptide-1: Improved bioavailability and anti-diabetic effect

Junko Hanato, Kazuki Kuriyama, Takahiro Mizumoto, +4

International Journal of Pharmaceutics

Lipid PreparationBiochemistryMedicineInsulin ManagementDiabetes +5

Inhalable powder formulation of a stabilized vasoactive intestinal peptide (VIP) derivative: Anti-inflammatory effect in experimental asthmatic rats

Shingen Misaka, Yosuke Aoki, Shin-ichiro Karaki, +4

Peptides

AsthmaInhalable Powder FormulationInflammationAnti-inflammatoryMedicine +5

Comparative studies on physicochemical stability of cyclosporine A-loaded amorphous solid dispersions

Hideyuki Sato, Yohei Kawabata, Kayo Yuminoki, +6

International Journal of Pharmaceutics

Materials ScienceEngineeringPolymer ScienceMicroemulsionPhysicochemical Stability +4

Self-micellizing solid dispersion of cyclosporine A for pulmonary delivery: Physicochemical, pharmacokinetic and safety assessments

Hiroki Suzuki, Kodai Ueno, Takahiro Mizumoto, +3

European Journal of Pharmaceutical Sciences

Lung DepositionPharmacologyPulmonary DeliveryPulmonary PharmacologyCyclosporine A +4

Inhalable Sustained-Release Formulation of Glucagon: In Vitro Amyloidogenic and Inhalation Properties, and In Vivo Absorption and Bioactivity

Satomi Onoue, Kazuki Kuriyama, Takahiro Mizumoto, +1

Pharmaceutical Research

Inhalation PropertiesVivo AbsorptionInhalable Sustained-release FormulationPharmacologyRelease Mechanism