Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density

W. Scott Simonet, Dave Lacey, Colin R. Dunstan, +26

Cell

SclerostinBiochemistryBone Morphogenic ProteinCell SignalingMedicine +11

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

Young‐Yun Kong, Hiroki Yoshida, Ildiko Sarosi, +14

Nature

Developmental BiologyKey RegulatorBone Morphogenic ProteinCell SignalingLymphocyte Development +9

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

Young‐Yun Kong, Ulrich Feige, Iidiko Sarosi, +17

Nature

InflammationRheumatologyRheumatoid DisorderSclerostinAdjuvant Arthritis +12

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

Mark Lomaga, Wen‐Chen Yeh, Ildiko Sarosi, +20

Genes & Development

RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism

Ji Li, Ildiko Sarosi, Xiaoqiang Yan, +20

Proceedings of the National Academy of Sciences

T-cell co-stimulation through B7RP-1 and ICOS

Steven K. Yoshinaga, John Whoriskey, Sanjay D. Khare, +23

Nature

T-cell Co-stimulationSignal TransductionAdaptive Immune SystemT-regulatory CellImmunology +5

The Ligand for Osteoprotegerin (OPGL) Directly Activates Mature Osteoclasts

Teresa L. Burgess, Yixin Qian, Stephen A. Kaufman, +9

The Journal of Cell Biology

Mature OcsOrthopaedic SurgeryOsteoporosisCellular PhysiologyBone Biology +15

Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice

Sanjay D. Khare, Ildiko Sarosi, Xing-Zhong Xia, +13

Proceedings of the National Academy of Sciences

B Cell HyperplasiaImmunologyPathologyImmunotherapyInflammation +15

Osteoprotegerin Reverses Osteoporosis by Inhibiting Endosteal Osteoclasts and Prevents Vascular Calcification by Blocking a Process Resembling Osteoclastogenesis

Hosung Min, Sean Morony, Ildiko Sarosi, +9

The Journal of Experimental Medicine

SclerostinOsteoporosisOrthopaedic SurgeryPrevents Vascular CalcificationBone Morphogenic Protein +15

Denosumab, a Fully Human Monoclonal Antibody to RANKL, Inhibits Bone Resorption and Increases BMD in Knock-In Mice That Express Chimeric (Murine/Human) RANKL

Paul J. Kostenuik, Hung Q. Nguyen, James McCabe, +22

Journal of Bone and Mineral Research