Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, Kotb Abdelmohsen, Akihisa Abe, +2329

Autophagy

Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques

Ju‐Hyun Lee, Dun‐Sheng Yang, Chris N. Goulbourne, +14

Nature Neuroscience

Atomic View of a Toxic Amyloid Small Oligomer

Arthur Laganowsky, Cong Liu, M.R. Sawaya, +10

Science

Amyloid OligomersProtein AssemblyMolecular BiologyPeptide ScienceAnalytical Ultracentrifugation +14

A causative link between the structure of aberrant protein oligomers and their toxicity

Silvia Campioni, Benedetta Mannini, Mariagioia Zampagni, +8

Nature Chemical Biology

Aberrant Protein OligomersCausative LinkProtein FunctionBiochemistryProtein Assembly +8

Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia

Irina A. Buhimschi, Unzila Nayeri, Guomao Zhao, +6

Science Translational Medicine

Molecular BiologyGynecologyNeurochemical BiomarkersAnalytical UltracentrifugationAmyloid Precursor Protein +16

Annular Protofibrils Are a Structurally and Functionally Distinct Type of Amyloid Oligomer

Rakez Kayed, Anna Pensalfini, Larry Margol, +5

Journal of Biological Chemistry

Amyloid OligomersProteinlipid InteractionApf FormationAlzheimer's DiseasePrecursor Pfos +12

Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction

Jennifer L. Tomic, Anna Pensalfini, Elizabeth Head, +1

Neurobiology of Disease

Alzheimer's DiseaseDementiaCognitive DysfunctionVascular DementiaNeurochemical Biomarkers +7

Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer’s disease

Sung‐Hoon Kim, Yutaka Sato, Panaiyur S. Mohan, +5

Molecular Psychiatry

Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates

Cong Liu, Minglei Zhao, Lin Jiang, +9

Proceedings of the National Academy of Sciences

Protein ChemistryBiochemistryProtein AssemblyProtein FoldingAmyloid Fibrils +12

Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers

Rakez Kayed, Isabel Canto, Leonid Breydo, +9

Molecular Neurodegeneration