Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities

Raffaella Carpenedo, Alberto Chiarugi, P. Russi, +5

Neuroscience

NeurophysiologyKynurenine HydroxylaseCerebral FormationMedicineNeuropharmacology +9

Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia

Flavio Moroni, Elena Meli, Fiamma Peruginelli, +6

Cell Death and Differentiation

ApoptosisCell DeathExperimental ModelsCerebral Vascular RegulationStroke +14

Astrocyte‐derived kynurenic acid modulates basal and evoked cortical acetylcholine release

Amy Zmarowski, Hui‐Qiu Wu, Julie M. Brooks, +4

European Journal of Neuroscience

Kyna PerfusionCortical Acetylcholine ReleaseSynaptic TransmissionNeurotransmitterNeurotransmission +20

Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum

Laura Amori, Hui‐Qiu Wu, Maura Marinozzi, +3

Neuroscience

Molecular PharmacologySpecific InhibitionMolecular NeuroscienceNeurophysiologyMedicine +9

C₃‐Fullero‐<i>tris</i>‐Methanodicarboxylic Acid Protects Cerebellar Granule Cells from Apoptosis

Michela Bisaglia, Benedetto Natalini, R. Pellicciari, +4

Journal of Neurochemistry

Redox SignalingNeurodegenerative DiseasesBiochemistryMedicineNatural Sciences +12

Cortical kynurenic acid bi-directionally modulates prefrontal glutamate levels as assessed by microdialysis and rapid electrochemistry

Åsa Konradsson‐Geuken, Hui‐Qiu Wu, Clelland R. Gash, +6

Neuroscience

NeurophysiologyNeuroanatomySynaptic TransmissionNeurotransmitterCortical Kynurenic Acid +11

Nicotinylalanine Increases the Formation of Kynurenic Acid in the Brain and Antagonizes Convulsions

P. Russi, Marina Alesiani, Giovanni Lombardi, +3

Journal of Neurochemistry

Synaptic TransmissionNeurotransmitterNeurotransmissionKyna SynthesisSocial Sciences +18

Long‐lasting neuroprotection and neurological improvement in stroke models with new, potent and brain permeable inhibitors of poly(ADP‐ribose) polymerase

Flavio Moroni, Andrea Cozzi, Alberto Chiarugi, +8

British Journal of Pharmacology

Selective PARP‐2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post‐ischaemic brain damage

Flavio Moroni, Laura Formentini, Elisabetta Gerace, +4

British Journal of Pharmacology

Dynamic ligand‐exchange chiral stationary phase from S‐benzyl‐(<i>R</i>)‐cysteine

Benedetto Natalini, Roccaldo Sardella, Antonio Macchiarulo, +1

Chirality