Potassium ion transport across myocardial cell membrane is essential for type 2 long QT syndrome (LQT2). However, the dysfunction of potassium ion transport due to genetic mutations limits the therapeutic effect in treating LQT2. Biomimetic ion channels that selectively and efficiently transport potassium ions across the cellular membranes are promising for the treatment of LQT2. To corroborate this, we synthesized a series of foldamer-based ion channels with different side chains, and found a biomimetic ion channel of K⁺ (BIC_K) with the highest transport activity among them. The selected BIC_K can restore potassium ion transport and increase transmembrane potassium ion current, thus shortening phase 3 of action potential (AP) repolarization and QT interval in LQT2. Moreover, BIC_K does not affect heart rate and cardiac rhythm in treating LQT2 model induced by E4031 in isolated heart as well as in guinea pigs. By restoring ion transmembrane transport tactic, biomimetic ion channels, such as BIC_K, will show great potential in treating diseases related to ion transport blockade. STATEMENT OF SIGNIFICANCE: Type 2 long QT syndrome (LQT2) is a disease caused by K⁺ transport disorder, which can cause malignant arrhythmia and even death. There is currently no radical cure, so it is critical to explore ways to improve K⁺ transmembrane transport. In this study, we report that a small-molecule biomimetic ion channel BIC_K can efficiently simulate natural K⁺ channel proteins on the cardiomyocyte and cure E4031-induced LQT2 in guinea pig by restoring K⁺ transport function for the first time. This study found that the potassium transmembrane transport by BIC_K significantly reduced the QT interval, which provides a conceptually new strategy for the treatment of LQT2 disease.

#	Concept	H-Index	Publications	Citations
1	Medicine	1	1	14
2	Diabetes	1	1	14
3	Epidemiology	1	1	14
4	Hepatology	1	1	14
5	Pathology	1	1	14

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