9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

Arthur A. Levin, Laurie J. Sturzenbecker, Sonja Kazmer, +8

Nature

Nuclear Receptor RxrαSignal TransductionMolecular PhysiologyMolecular RegulationNatural Sciences +6

Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids.

Gary Allenby, M. T. Bocquel, Michael A. Saunders, +7

Proceedings of the National Academy of Sciences

Molecular PharmacologyPhotoreceptor CellSignal TransductionRetinaBiochemistry +13

Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development

Binh Thanh Vu, Peter M. Wovkulich, Giacomo Pizzolato, +11

ACS Medicinal Chemistry Letters

Drug TargetCell DeathSmall-molecule Mdm2 InhibitorTumor BiologyP53 Activity +15

Synthetic applications and mechanism studies of the decarbalkoxylations of geminal diesters and related systems effected in dimethyl sulfoxide by water and/or by water with added salts

A. Paul Krapcho, John F. Weimaster, J. M. ELDRIDGE, +3

The Journal of Organic Chemistry

Chemical EngineeringDimethyl SulfoxideEngineeringChemical MeasurementChemical Analysis +12

Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization

Bradford Graves, Thelma Thompson, Mingxuan Xia, +12

Proceedings of the National Academy of Sciences

Dimeric Protein ComplexesMolecular BiologyMdmx DimerizationCancer BiologyAnti-cancer Agent +14

Decarbalkoxylations of geminal diesters, β-keto esters and α-cyano esters effected by sodium chloride in dimethyl sulpoxide

A. Paul Krapcho, Allen Lovey

Tetrahedron Letters

Sodium ChlorideDimethyl SulpoxideEngineeringBiochemistryGeminal Diesters +7

Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), A Potent and Selective Cyclin-Dependent Kinase Inhibitor with Significant in Vivo Antitumor Activity

Xin‐Jie Chu, Wanda DePinto, David Bartkovitz, +18

Journal of Medicinal Chemistry

Drug TargetPharmacotherapyCell CycleChemical BiologyPharmaceutical Chemistry +15

<i>In vitro</i> and <i>in vivo</i> activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials

Wanda DePinto, Xin‐Jie Chu, Xuefeng Yin, +17

Molecular Cancer Therapeutics

Molecular PharmacologyTumor BiologyCell Cycle BlockBiochemistryMedicine +13

Decarbalkoxylations of geminal diesters and β-keto esters in wet dimethyl sulfoxide. Effect of added sodium chloride on the decarbalkoxylation rates of mono- and di-substituted Malonate esters

A. Paul Krapcho, Edwin G. E. Jahngen, Allen Lovey, +1

Tetrahedron Letters

EngineeringBiochemistryGeminal DiestersWet Dimethyl SulfoxideOrganic Chemistry +5

Fluorinated retinoic acids and their analogs. 3. Synthesis and biological activity of aromatic 6-fluoro analogs

Allen Lovey, Beverly A. Pawson

Journal of Medicinal Chemistry