Objective.This study presents the first clinical implementation of an efficient online daily adaptive proton therapy workflow (DAPT).Approach.The DAPT workflow includes apre-treatment phase,where atemplateand afallback planare optimized on the planning computed tomography (CT). In theonline phase, theadapted planis re-optimized on daily images from an in-room CT. Daily structures are rigidly propagated from the planning CT. Automated Quality Assurance (QA) involves geometric, sanity checks and an independent dose calculation from the machine files. Differences from the template plan are analyzed field-by-field, and clinical plan is assessed by reviewing the achieved clinical goals using a traffic light protocol. If the daily adapted plan fails any QA or clinical goals, the fallback plan is used. In theoffline phasethe delivered dose is recalculated from log-files onto the daily CT, and a gamma analysis is performed (3%/3 mm). The DAPT workflow has been applied to selected adult patients treated in rigid anatomy for the last serie of the treatment between October 2023 and April 2024.Main Results.DAPT treatment sessions averaged around 23 min [range: 15-30 min] and did not exceed the typical 30 minute time slot. Treatment adaptation, including QA and clinical plan assessment, averaged just under 7 min [range: 3:30-16 min] per fraction. All plans passed the online QAs steps. In the offline phase a good agreement with the log-files reconstructed dose was achieved (minimum gamma pass rate of 97.5%). The online adapted plan was delivered for >85% of the fractions. In 92% of total fractions, adapted plans exhibited improved individual dose metrics to the targets and/or organs at risk.Significance.This study demonstrates the successful implementation of an online daily DAPT workflow. Notably, the duration of a DAPT session did not exceed the time slot typically allocated for non-DAPT treatment. As far as we are aware, this is a first clinical implementation of daily online adaptive proton therapy.

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