Hans-Dieter Höltje

A Combined QM/MM Approach to Protein−Ligand Interactions:  Polarization Effects of the HIV-1 Protease on Selected High Affinity Inhibitors

Christian Hensen, Johannes C. Hermann, Kwangho Nam et al. · Journal of Medicinal Chemistry · 2004 · 119 citations

Natural Sciences, Medicinal Chemistry, Pharmacology +17

Allosteric Site on Muscarinic Acetylcholine Receptors: Identification of Two Amino Acids in the Muscarinic M2 Receptor That Account Entirely for the M2/M5 Subtype Selectivities of Some Structurally Diverse Allosteric Ligands in N-Methylscopolamine-Occupied Receptors

Uta Voigtländer, Kirstin Jöhren, Marion Mohr et al. · Molecular Pharmacology · 2003 · 89 citations

Medicine, Neuroscience, Pharmacology +17

Key Determinants of Nucleotide-Activated G Protein-Coupled P2Y₂ Receptor Function Revealed by Chemical and Pharmacological Experiments, Mutagenesis and Homology Modeling

Petra Hillmann, Geun-Yung Ko, Andreas Spinrath et al. · Journal of Medicinal Chemistry · 2009 · 77 citations · Full text

Medicine, Biochemistry, Pharmacology +17

Interactions of gallic acid, resveratrol, quercetin and aspirin at the platelet cyclooxygenase-1 level Functional and modelling studies

Marilena Crescente, Gisela Jessen, Stefania Momi et al. · Thrombosis and Haemostasis · 2009 · 73 citations

Medicine, Biochemistry, Pharmacology +17

Allosteric Interactions with Muscarinic Acetylcholine Receptors: Complex Role of the Conserved Tryptophan M2422Trp in a Critical Cluster of Amino Acids for Baseline Affinity, Subtype Selectivity, and Cooperativity

Stefanie Prilla, Jasmin Schrobang, John E. Ellis et al. · Molecular Pharmacology · 2006 · 60 citations

Medicine, Biochemistry, Pharmacology +17