R. W. Friesen

The YRD Motif Is a Major Determinant of Substrate and Inhibitor Specificity in T-cell Protein-tyrosine Phosphatase

Ernest Asante‐Appiah, Kristen Ball, Kevin P. Bateman et al. · Journal of Biological Chemistry · 2001 · 50 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Conformation-assisted Inhibition of Protein-tyrosine Phosphatase-1B Elicits Inhibitor Selectivity over T-cell Protein-tyrosine Phosphatase

Ernest Asante‐Appiah, Sangita B. Patel, Caroline Desponts et al. · Journal of Biological Chemistry · 2006 · 42 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Discovery of 4-{1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain

John Colucci, Michael J. Boyd, Carl Berthelette et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 39 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

The Discovery of 4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic Acid (MK-2894), A Potent and Selective Prostaglandin E₂Subtype 4 Receptor Antagonist

Marc Blouin, Yongxin Han, Jason D. Burch et al. · Journal of Medicinal Chemistry · 2010 · 34 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

Design, synthesis, and evaluation of novel 3-amino-4-hydrazine-cyclobut-3-ene-1,2-diones as potent and selective CXCR2 chemokine receptor antagonists

Shilan Liu, Yinhui Liu, Hongmei Wang et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 13 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14