Tak W. Mak

Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice

JoAnne L. Flynn, Marsha M. Goldstein, John Chan et al. · Immunity · 1995 · 1.7K citations · Full text

ICOS is essential for effective T-helper-cell responses

Arda Shahinian, Friedhelm Bladt, Steve K. Yoshinaga et al. · Nature · 2001 · 664 citations

Adaptive Immune System, T-regulatory Cell, Immunology +8

A point mutation in CD28 distinguishes proliferative signals from survival signals

Klaus Okkenhaug, Linda Wu, Kristine M. Garza et al. · Nature Immunology · 2001 · 202 citations

Survival Signals, Signal Transduction, Signaling Pathway +9

Role of ICOS versus CD28 in antiviral immunity

Edward M. Bertram, Arda Shahinian, Vera S. F. Chan et al. · European Journal of Immunology · 2002 · 88 citations

CD8 is needed for positive selection but differentially required for negative selection of T cells during thymic ontogeny

Wai‐Ping Fung‐Leung, Valerie A. Wallace, Dawn Gray et al. · European Journal of Immunology · 1993 · 69 citations