Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

Sadia Saeed, Jessica Quintin, Hindrik H. D. Kerstens, +27

Science

Trained ImmunityAdaptive Immune SystemInnate Immune SystemImmunologyImmune Regulation +16

Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters

Biola M. Javierre, Oliver S. Burren, Steven P. Wilder, +36

Cell

Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells

Lu Chen, Bing Ge, Francesco Paolo Casale, +73

Cell

Transcriptional diversity during lineage commitment of human blood progenitors

Lu Chen, Myrto Kostadima, Joost H.A. Martens, +62

Science

Increased DNA methylation variability in type 1 diabetes across three immune effector cell types

Dirk S. Paul, Andrew E. Teschendorff, Mary Dang, +40

Nature Communications

Chromosome contacts in activated T cells identify autoimmune disease candidate genes

Oliver S. Burren, Arcadio Rubio García, Biola M. Javierre, +20

Genome biology

Genetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease

Stephen M. Watt, Louella Vasquez, Klaudia Walter, +24

Nature Communications

Distinct Trends of DNA Methylation Patterning in the Innate and Adaptive Immune Systems

Ronald P. Schuyler, Angelika Merkel, Emanuele Raineri, +17

Cell Reports

Platelet function is modified by common sequence variation in megakaryocyte super enhancers

R. Petersen, John Lambourne, Biola M. Javierre, +56

Nature Communications

Novel manifestations of immune dysregulation and granule defects in gray platelet syndrome

Matthew C. Sims, Louisa Mayer, Janine Collins, +49

Blood