John Osborne

Identification of the Tuberous Sclerosis Gene <i>TSC1</i> on Chromosome 9q34

Marjon van Slegtenhorst, Ronald De Hoogt, Caroline Hermans et al. · Science · 1997 · 1.7K citations

Medicine, Genetics, Molecular Genetics +16

The United Kingdom Infantile Spasms Study (UKISS) comparing hormone treatment with vigabatrin on developmental and epilepsy outcomes to age 14 months: a multicentre randomised trial

Andrew Lux, Stuart W. Edwards, Eleanor Hancock et al. · The Lancet Neurology · 2005 · 401 citations

Medicine, Pediatrics, Pharmacotherapy +12

The United Kingdom Infantile Spasms Study comparing vigabatrin with prednisolone or tetracosactide at 14 days: a multicentre, randomised controlled trial

Andrew Lux, Stuart W. Edwards, Eleanor Hancock et al. · The Lancet · 2004 · 378 citations

Pharmacy, Neurology, Pharmacotherapy +6

The effect of lead time to treatment and of age of onset on developmental outcome at 4 years in infantile spasms: Evidence from the United Kingdom Infantile Spasms Study

Finbar O’Callaghan, Andrew Lux, Katrina Darke et al. · Epilepsia · 2011 · 288 citations

Medicine, Human Development, Pediatrics +12

Safety and effectiveness of hormonal treatment versus hormonal treatment with vigabatrin for infantile spasms (ICISS): a randomised, multicentre, open-label trial

Finbar O’Callaghan, Stuart W. Edwards, Fabienne Dietrich Alber et al. · The Lancet Neurology · 2016 · 286 citations · Full text

Medicine, Endocrinology, Pharmacotherapy +8