Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody

Wanchao Yin, Youwei Xu, Peiyu Xu, +22

Science

Virus StructureViral EvolutionOmicron Spike TrimerAnti-omicron AntibodyViral Pathogenesis +8

Structures of the entire human opioid receptor family

Yue Wang, Youwen Zhuang, Jeffrey F. DiBerto, +9

Cell

Molecular PharmacologyFunctional SelectivityMedicineReceptor (Biochemistry)Molecular Biology +5

GPCR activation and GRK2 assembly by a biased intracellular agonist

Jia Duan, Heng Liu, Fenghui Zhao, +15

Nature

Molecular PharmacologySignal TransductionMolecular PhysiologySignaling PathwayG Protein-coupled Receptor +9

Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins

Youwei Xu, Canrong Wu, Xiaodan Cao, +12

Cell Research

Hormone- and antibody-mediated activation of the thyrotropin receptor

Jia Duan, Peiyu Xu, Xiaodong Luan, +10

Nature

Thyrotropin ReceptorEndocrine MechanismHormonal ReceptorImmunologyAutoimmunity +3

Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins

Yue Wang, Weiyi Liu, Youwei Xu, +10

Nature Chemical Biology

InflammationComplement Receptors C3arComplement SystemSignal TransductionAllergy +8

Recognition of methamphetamine and other amines by trace amine receptor TAAR1

Heng Liu, You Zheng, Yue Wang, +14

Nature

Molecular PharmacologyPsychoactive DrugMedicineOther AminesForensic Toxicology +4

Conserved class B GPCR activation by a biased intracellular agonist

Lihua Zhao, He Qian, Qingning Yuan, +9

Nature

Molecular PharmacologySignal TransductionMolecular PhysiologySignaling PathwayFunctional Selectivity +10

Insights into divalent cation regulation and G13-coupling of orphan receptor GPR35

Jia Duan, Qiufeng Liu, Qingning Yuan, +10

Cell Discovery

Dimerization and antidepressant recognition at noradrenaline transporter

Heng Zhang, Yu-Ling Yin, Antao Dai, +12

Nature

NeurophysiologyMedicineNoradrenaline TransporterPsychopharmacologyNeuropharmacology +4