Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis

Emma Guttman‐Yassky, Robert Bissonnette, Benjamin Ungar, +17

Journal of Allergy and Clinical Immunology

The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization

Shinji Noda, Mayte Suárez‐Fariñas, Benjamin Ungar, +13

Journal of Allergy and Clinical Immunology

InflammationIncreased Th17 PolarizationAtopic DermatitisImmunologyClinical Dermatology +3

Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response

Nikhil Dhingra, Avner Shemer, Joel Corrêa da Rosa, +12

Journal of Allergy and Clinical Immunology

Autoimmune DiseaseAllergySkin TestingAtopic DermatitisImmunology +7

RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications

Mayte Suárez‐Fariñas, Benjamin Ungar, Joel Corrêa da Rosa, +10

Journal of Allergy and Clinical Immunology

BioinformaticsAutoimmune DiseaseAtopic DermatitisMedicineNovel Disease Mechanisms +10

Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17/TH22 skewing

Mayte Suárez‐Fariñas, Benjamin Ungar, Shinji Noda, +12

Journal of Allergy and Clinical Immunology

InflammationCytokineParallel Th17/th22 SkewingAutoimmune DiseaseImmunology +6

Early-onset pediatric atopic dermatitis is characterized by TH2/TH17/TH22-centered inflammation and lipid alterations

Patrick M. Brunner, Ariel Israel, Ning Zhang, +14

Journal of Allergy and Clinical Immunology

InflammationTh2/th17/th22-centered InflammationAtopic DermatitisImmunologySkin Allergy +6

Severe atopic dermatitis is characterized by selective expansion of circulating TH2/TC2 and TH22/TC22, but not TH17/TC17, cells within the skin-homing T-cell population

Tali Czarnowicki, Juana Gonzalez, Avner Shemer, +9

Journal of Allergy and Clinical Immunology

InflammationSkin-homing T-cell PopulationAtopic DermatitisT-regulatory CellImmunology +8

Identification of novel immune and barrier genes in atopic dermatitis by means of laser capture microdissection

Hitokazu Esaki, David Ewald, Benjamin Ungar, +10

Journal of Allergy and Clinical Immunology

Barrier GenesAtopic DermatitisImmunologySkin AllergyLaser Capture Microdissection +6

GBR 830, an anti-OX40, improves skin gene signatures and clinical scores in patients with atopic dermatitis

Emma Guttman‐Yassky, Ana B. Pavel, Lisa Zhou, +16

Journal of Allergy and Clinical Immunology

Early pediatric atopic dermatitis shows only a cutaneous lymphocyte antigen (CLA)+ TH2/TH1 cell imbalance, whereas adults acquire CLA+ TH22/TC22 cell subsets

Tali Czarnowicki, Hitokazu Esaki, Juana Gonzalez, +14

Journal of Allergy and Clinical Immunology

Pediatric Atopic DermatitisAllergyAtopic DermatitisTh2/th1 Cell ImbalanceImmunology +7