Qinggang Zhang

Mutation-Induced Impacts on the Switch Transformations of the GDP- and GTP-Bound K-Ras: Insights from Multiple Replica Gaussian Accelerated Molecular Dynamics and Free Energy Analysis

Jianzhong Chen, Shaolong Zhang, Wei Wang et al. · Journal of Chemical Information and Modeling · 2021 · 142 citations

Engineering, Molecular Biology, Mutation-induced Impacts +16

A Comparative Insight into Amprenavir Resistance of Mutations V32I, G48V, I50V, I54V, and I84V in HIV-1 Protease Based on Thermodynamic Integration and MM-PBSA Methods

Jianzhong Chen, Xingyu Wang, Tong Zhu et al. · Journal of Chemical Information and Modeling · 2015 · 125 citations

Viral Replication, Molecular Biology, Computational Chemistry +18

Revealing Origin of Decrease in Potency of Darunavir and Amprenavir against HIV-2 relative to HIV-1 Protease by Molecular Dynamics Simulations

Jianzhong Chen, Zhiqiang Liang, Wei Wang et al. · Scientific Reports · 2014 · 68 citations · Full text

Hiv-1 Protease, Engineering, Medicine +15

Effect of electrostatic polarization and bridging water on CDK2–ligand binding affinities calculated using a highly efficient interaction entropy method

Lili Duan, Guoqiang Feng, Xianwei Wang et al. · Physical Chemistry Chemical Physics · 2017 · 55 citations

Targeting bromodomain-containing protein 4 (BRD4) benefits rheumatoid arthritis

Qinggang Zhang, Jing Qian, Yuchang Zhu · Immunology Letters · 2015 · 54 citations

Inflammation, Rheumatology, Rheumatoid Disorder +8