Jia Chen

Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing

Zhen Liu, Zongyang Lu, Guang Yang et al. · Nature Communications · 2018 · 2.1K citations · Full text

Camrelizumab versus investigator's choice of chemotherapy as second-line therapy for advanced or metastatic oesophageal squamous cell carcinoma (ESCORT): a multicentre, randomised, open-label, phase 3 study

Jing Huang, Jianming Xu, Yun Chen et al. · The Lancet Oncology · 2020 · 568 citations

Esophageal Cancer, Gastrointestinal Oncology, Medicine +10

A cis-regulatory map of the Drosophila genome

Nicolas Nègre, Lijia Ma, Christopher A. Bristow et al. · Nature · 2011 · 531 citations

Transcriptional Regulation, Genetics, Genomic Mechanism +5

Base editing with a Cpf1–cytidine deaminase fusion

Xiaosa Li, Ying Wang, Yajing Liu et al. · Nature Biotechnology · 2018 · 416 citations

Nucleic Acid Chemistry, Cpf1–cytidine Deaminase Fusion, Molecular Biology +4

Efficient base editing in methylated regions with a human APOBEC3A-Cas9 fusion

Xiao Wang, Jianan Li, Ying Wang et al. · Nature Biotechnology · 2018 · 263 citations

Chromatin, Biochemistry, Human Apobec3a-cas9 Fusion +10