Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes

Tongyan Liu, Changxiang Shi, Run Gao, +8

Clinical Science

Glucose ProductionMetabolic RemodelingInsulin SignalingOxidative StressMetabolic Syndrome +18

A nanomaterial-based breath test for distinguishing gastric cancer from benign gastric conditions

Z-q Xu, Yoav Y. Broza, R Ionsecu, +11

British Journal of Cancer

FNDC5 overexpression and irisin ameliorate glucose/lipid metabolic derangements and enhance lipolysis in obesity

Xiao‐Qing Xiong, Dan Chen, Hai‐Jian Sun, +10

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

ObesityMetabolic SyndromeFndc5 OverexpressionBiochemistryPhysiology +9

Serum Proprotein Convertase Subtilisin/Kexin Type 9 and Cell Surface Low-Density Lipoprotein Receptor

Hagai Tavori, Daping Fan, John Blakemore, +4

Circulation

Local effects of human <scp>PCSK9</scp> on the atherosclerotic lesion

Ilaria Giunzioni, Hagai Tavori, Roman Covarrubias, +10

The Journal of Pathology

Vascular DiseaseImmunologyPathologyHpcsk9 ExpressionHyperlipidemia +14

Macrophage LRP-1 Controls Plaque Cellularity by Regulating Efferocytosis and Akt Activation

Patricia G. Yancey, John Blakemore, Lei Ding, +5

Arteriosclerosis Thrombosis and Vascular Biology

Macrophage SR-BI mediates efferocytosis via Src/PI3K/Rac1 signaling and reduces atherosclerotic lesion necrosis

Tao Huan, Patricia G. Yancey, Vladimir R. Babaev, +5

Journal of Lipid Research

Macrophage EP4 Deficiency Increases Apoptosis and Suppresses Early Atherosclerosis

Vladimir R. Babaev, Joshua D. Chew, Lei Ding, +6

Cell Metabolism

InflammationSuppresses Early AtherosclerosisVascular DiseaseImmunologyChronic Inflammation +5

Self-Association of Human PCSK9 Correlates with Its LDLR-Degrading Activity

Daping Fan, Patricia G. Yancey, Shenfeng Qiu, +4

Biochemistry

Human PolymorphismPathologyHuman Pcsk9Plasma Cholesterol LevelsPcsk9 Protein +14

HIF-2α upregulation mediated by hypoxia promotes NAFLD-HCC progression by activating lipid synthesis via the PI3K-AKT-mTOR pathway

Jianxu Chen, Jiandi Chen, Jiaxin Huang, +11

Aging