Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice

Luc Baeyens, M. Lemper, Gunter Leuckx, +18

Nature Biotechnology

InflammationCytokineDiabetesCell ReprogrammingImmunology +8

Neurogenin 3+ cells contribute to β-cell neogenesis and proliferation in injured adult mouse pancreas

Mark Van de Casteele, G. Leuckx, Luc Baeyens, +13

Cell Death and Disease

Estrogen Receptor α Regulates β-Cell Formation During Pancreas Development and Following Injury

Yixing Yuchi, Ying Cai, Bart Legein, +10

Diabetes

Insulin SignalingTranscriptional RegulationSignaling PathwayCell RegulationEstrogen Receptor α +19

Macrophage dynamics are regulated by local macrophage proliferation and monocyte recruitment in injured pancreas

Naomi Van Gassen, Eva Van Overmeire, Gunter Leuckx, +11

European Journal of Immunology

Macrophage DynamicsImmunologyPathologyImmune SystemCellular Physiology +15

Partial Duct Ligation: β-Cell Proliferation and Beyond

Mark Van de Casteele, Gunter Leuckx, Ying Cai, +8

Diabetes

Progenitor CellsPartial Duct LigationAdult Stem CellImmune RegulationCell Proliferation +23

Sexual Dimorphism in Metabolic Responses to Western Diet in Drosophila melanogaster

Sofie De Groef, Tom Wilms, Séverine Balmand, +2

Biomolecules

Vegf-A mRNA transfection as a novel approach to improve mouse and human islet graft revascularisation

Willem Staels, Yannick Verdonck, Yves Heremans, +9

Diabetologia

Regenerative MedicineIslet TransplantationDevelopmental BiologyXenotransplantationMedicine +8

STAT3 modulates β-cell cycling in injured mouse pancreas and protects against DNA damage

Sofie De Groef, Dries Renmans, Ying Cai, +11

Cell Death and Disease

Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation

Sofie De Groef, Gunter Leuckx, Naomi Van Gassen, +9

Journal of Visualized Experiments

Beta Cell ProliferationImmunologyPancreas TransplantationCell SpecializationInsulin Signaling +21

A combination of cytokines EGF and CNTF protects the functional beta cell mass in mice with short-term hyperglycaemia

M. Lemper, Sofie De Groef, Geert Stangé, +2

Diabetologia

InflammationMetabolic SyndromeCytokineInsulin SignalingCytokines Egf +9