Pgp-Mediated Interaction Between (R)-[11C]Verapamil and Tariquidar at the Human Blood–Brain Barrier: A Comparison With Rat Data

Martin Bauer, Markus Zeitlinger, Rudolf Karch, +12

Clinical Pharmacology & Therapeutics

Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[11C]verapamil PET

Claudia Kuntner, Jens P. Bankstahl, Marion Bankstahl, +10

European Journal of Nuclear Medicine and Molecular Imaging

Pharmacological StudyP-glycoprotein InhibitionMedicineDose-response AssessmentNeuropharmacology +7

Tariquidar-Induced P-Glycoprotein Inhibition at the Rat Blood–Brain Barrier Studied with (<i>R</i>)-¹¹C-Verapamil and PET

Jens P. Bankstahl, Claudia Kuntner, Aiman Abrahim, +8

Journal of Nuclear Medicine

Tariquidar and Elacridar Are Dose-Dependently Transported by P-Glycoprotein and Bcrp at the Blood-Brain Barrier: A Small-Animal Positron Emission Tomography and In Vitro Study

Jens P. Bankstahl, Marion Bankstahl, Kerstin Römermann, +9

Drug Metabolism and Disposition

Limitations of Small Animal PET Imaging with [18F]FDDNP and FDG for Quantitative Studies in a Transgenic Mouse Model of Alzheimer’s Disease

Claudia Kuntner, Adam Kesner, Martin Bauer, +8

Molecular Imaging and Biology

Positron Emission TomographyNeurodegenerative DiseasesQuantitative StudiesAlzheimer's DiseaseEngineering +10

Approaching Complete Inhibition of P-Glycoprotein at the Human Blood–Brain Barrier: An (<i>R</i>)-[¹¹C]Verapamil PET Study

Martin Bauer, Rudolf Karch, Markus Zeitlinger, +9

Journal of Cerebral Blood Flow & Metabolism

Design, Synthesis, and Evaluation of a Low-Molecular-Weight ¹¹C-Labeled Tetrazine for Pretargeted PET Imaging Applying Bioorthogonal in Vivo Click Chemistry

Christoph Denk, Dennis Svatunek, Severin Mairinger, +6

Bioconjugate Chemistry

EngineeringImaging AgentPet-mriNaive MiceBiomedical Engineering +14

Synthesis and in vivo evaluation of [11C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor

Florian F. Bauer, Claudia Kuntner, Jens P. Bankstahl, +9

Bioorganic & Medicinal Chemistry

Medicinal ChemistryThird-generation P-glycoprotein InhibitorEngineeringVivo EvaluationMedicine +11

Synthesis and Small-Animal Positron Emission Tomography Evaluation of [¹¹C]-Elacridar As a Radiotracer to Assess the Distribution of P-Glycoprotein at the Blood−Brain Barrier

Bernd Dörner, Claudia Kuntner, Jens P. Bankstahl, +9

Journal of Medicinal Chemistry

EngineeringBrain Activity UptakePharmacotherapyExperimental PharmacologyGlioma +15

A Novel Positron Emission Tomography Imaging Protocol Identifies Seizure-Induced Regional Overactivity of P-Glycoprotein at the Blood-Brain Barrier

Jens P. Bankstahl, Marion Bankstahl, Claudia Kuntner, +7

Journal of Neuroscience

P-glycoprotein ModulationNeurochemical BiomarkersPharmacotherapyExperimental PharmacologyP-glycoprotein Activity +16