CAR T Cells Targeting Podoplanin Reduce Orthotopic Glioblastomas in Mouse Brains

Satoshi Shiina, Masasuke Ohno, Fumiharu Ohka, +16

Cancer Immunology Research

ImmunologyAntigen ProcessingMouse BrainsT CellsImmunotherapy +18

Efficacy of cancer-specific anti-podoplanin CAR-T cells and oncolytic herpes virus G47Δ combination therapy against glioblastoma

Lushun Chalise, Akira Kato, Masasuke Ohno, +11

Molecular Therapy — Oncolytics

MedicineImmunologyG47δ Combination TherapyImmune Checkpoint InhibitorOncolytic Herpes +8

Lenalidomide enhances the function of chimeric antigen receptor T cells against the epidermal growth factor receptor variant III by enhancing immune synapses

Shunichiro Kuramitsu, Masasuke Ohno, Fumiharu Ohka, +10

Cancer Gene Therapy

Immune SynapsesAutoimmune DiseaseT-regulatory CellImmune RegulationImmunology +7

Ultrasound frequency-controlled microbubble dynamics in brain vessels regulate the enrichment of inflammatory pathways in the blood-brain barrier

Yutong Guo, Hohyun Lee, Chulyong Kim, +8

Nature Communications

Tumour-wide RNA splicing aberrations generate actionable public neoantigens

Darwin Kwok, Nicholas Stevers, Iñaki Etxeberría, +28

Nature

Enhancing CAR-T cell metabolism to overcome hypoxic conditions in the brain tumor microenvironment

Ryusuke Hatae, Keith Kyewalabye, Akane Yamamichi, +7

JCI Insight

Brain Tumor MicroenvironmentChemoprevention StrategyImmunologyBiological MicroenvironmentsCar-t Cell Metabolism +21

Inhibition of D-2HG leads to upregulation of a proinflammatory gene signature in a novel HLA-A2/HLA-DR1 transgenic mouse model of IDH1R132H-expressing glioma

Pavlina Chuntova, Akane Yamamichi, Tiffany Chen, +13

Journal for ImmunoTherapy of Cancer

A novel high-sensitivity assay to detect a small fraction of mutant IDH1 using droplet digital PCR

Masaki Hirano, Fumiharu Ohka, Sachi Maeda, +12

Brain Tumor Pathology

EngineeringNucleic Acid BiomarkersMedicineGeneticsBioanalysis +11

Immunohistochemical ATRX expression is not a surrogate for 1p19q codeletion

Akane Yamamichi, Fumiharu Ohka, Kosuke Aoki, +10

Brain Tumor Pathology

Molecular ImmunologyImmunohistochemical Atrx ExpressionAutoimmune DiseaseMedicineNatural Sciences +6

A novel all-in-one intraoperative genotyping system for IDH1-mutant glioma

Fumiharu Ohka, Akane Yamamichi, Michihiro Kurimoto, +13

Brain Tumor Pathology

Tumor HeterogeneityPathologyIdh1-mutant GliomaMedicineGlioma +1