Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

Elisabetta Cameroni, John E. Bowen, Laura E. Rosen, +53

Nature

VaccinationNeutralizing AntibodiesVaccine TargetHumoral ResponseImmunology +4

Genetic Variation in IL28B Is Associated With Chronic Hepatitis C and Treatment Failure: A Genome-Wide Association Study

Andri Rauch, Zoltán Kutalik, Patrick Descombes, +24

Gastroenterology

Genome-wide Association StudyDisease SusceptibilityIl28b Is AssociatedAutoimmune DiseaseHepatitis C +12

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2

Matthew McCallum, Anna De Marco, Florian A. Lempp, +31

Cell

Viral PathogenesisImmunologyVirologyViral Structural ProteinMedicine +1

Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity

Emma C. Thomson, Laura E. Rosen, James G. Shepherd, +63

Cell

SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

Tyler N. Starr, Nadine Czudnochowski, Zhuoming Liu, +54

Nature

BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment

Georg Winter, Andreas Mayer, Dennis L. Buckley, +19

Molecular Cell

Transcriptional RegulationCell RegulationGeneticsGene RegulationCdk9 Recruitment +5

SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern

Matthew McCallum, Jessica Bassi, Anna De Marco, +29

Science

VaccinationNovel VariantViral EvolutionVaccine DevelopmentVaccine Target +13

Broad betacoronavirus neutralization by a stem helix–specific human antibody

Dora Pinto, Maximilian M. Sauer, Nadine Czudnochowski, +49

Science

Native Elongating Transcript Sequencing Reveals Human Transcriptional Activity at Nucleotide Resolution

Andreas Mayer, Julia di Iulio, Seth Maleri, +6

Cell

Transcriptional RegulationEngineeringGeneticsRna BiologyRna Sequencing +8

Deep sequencing of 10,000 human genomes

Amalio Telenti, Levi Pierce, William Biggs, +16

Proceedings of the National Academy of Sciences

GeneticsPathologyIndividual Human GenomeGenomicsHigh Throughput Sequencing +17