Alan M. Mathiowetz

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

Tina R. White, Chad M. Renzelman, Arthur C Rand et al. · Nature Chemical Biology · 2011 · 373 citations

Medicinal Chemistry, Biochemistry, Natural Sciences +7

Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules

Cameron R. Pye, William M. Hewitt, Joshua Schwochert et al. · Journal of Medicinal Chemistry · 2017 · 151 citations · Full text

Peptide Engineering, Peptide Science, Chemistry +25

A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor

David A. Griffith, David J. Edmonds, Jean‐Philippe Fortin et al. · Journal of Medicinal Chemistry · 2022 · 140 citations · Full text

Insulin Signaling, Gastrointestinal Peptide Hormone, Molecular Pharmacology +17

Are 2D fingerprints still valuable for drug discovery?

Kaifu Gao, Duc Duy Nguyen, Vishnu Sresht et al. · Physical Chemistry Chemical Physics · 2020 · 134 citations · Full text

Molecular Fingerprints, Drug Target, Engineering +19

Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products

Andrew T. Bockus, Katrina W. Lexa, Cameron R. Pye et al. · Journal of Medicinal Chemistry · 2015 · 133 citations