Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease

Wei-Ting Chen, Ashley Lu, Katleen Craessaerts, +20

Cell

Neurodegenerative DiseasesAlzheimer's DiseaseSpatial TranscriptomicsMedicineNeurology +6

Mitochondria metabolism sets the species-specific tempo of neuronal development

Ryohei Iwata, Pierre Casimir, Emir Erkol, +24

Science

Brain DevelopmentMitochondria MetabolismNeuronal DevelopmentOxidative StressHuman Brain Development +15

Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain

Ira Espuny-Camacho, Amaia M. Arranz, Mark Fiers, +17

Neuron

Neurodegenerative DiseasesAlzheimer's DiseaseMedicineStem Cell ResearchMouse Brain +9

Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy

Valerie Uytterhoeven, Elsa Lauwers, Ine Maes, +9

Neuron

Protein FunctionHsc70-4 Deforms MembranesNatural SciencesAutophagyEndocytic Pathway +8

SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells

Juan Antonio García‐León, Manoj Kumar, Ruben Boon, +15

Stem Cell Reports

Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments

Francesc X. Guix, Ragna Sannerud, Fedor Berditchevski, +17

Molecular Neurodegeneration

Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer’s disease mouse models

Yunhong Huang, Aneta Skwarek‐Maruszewska, Katrien Horré, +21

Science Translational Medicine

Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction

Dick W. Zijlmans, Irene Talón, Sigrid Verhelst, +33

Nature Cell Biology

Lineage PotentialEpigenetic ChangeGeneticsMolecular BiologyEpigenetics +20

High-content imaging and gene expression analysis to study cell–nanomaterial interactions: The effect of surface hydrophobicity

Bella B. Manshian, Daniel F. Moyano, Nikky Corthout, +4

Biomaterials

High-content ImagingEngineeringNovel Imaging MethodNanobiotechnologySurface Hydrophobicity +9

Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques

Pranav Preman, Julia TCW, Sara Calafate, +8

Molecular Neurodegeneration