In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration

Keiichiro Suzuki, Yuji Tsunekawa, Reyna Hernández‐Benítez, +32

Nature

In Vivo Gene TherapyGeneticsMolecular BiologyGenetic EngineeringGene Editing +4

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

Weiqi Zhang, Jingyi Li, Keiichiro Suzuki, +31

Science

Interspecies Chimerism with Mammalian Pluripotent Stem Cells

Jun Wu, Aida Platero-Luengo, Masahiro Sakurai, +34

Cell

Induced Pluripotent Stem CellAdult Stem CellInterspecies ChimerismStem CellsCell Biology +1

Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network

Jian Hui Low, Pin Li, Elaine Guo Yan Chew, +15

Cell stem cell

Patterned Nephron SegmentsDevelopmental BiologyMorphogenesisOrgan DevelopmentOrganoid Models +5

An alternative pluripotent state confers interspecies chimaeric competency

Jun Wu, Daiji Okamura, Mo Li, +24

Nature

Transitional JusticeGovernment AdministrationLaw

Targeted Gene Correction Minimally Impacts Whole-Genome Mutational Load in Human-Disease-Specific Induced Pluripotent Stem Cell Clones

Keiichiro Suzuki, Chang Yu, Jing Qu, +20

Cell stem cell

Induced Pluripotent Stem CellMedicineGeneticsWhole-genome Mutational LoadGenetic Engineering +7

Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs

Guang Hui Liu, Keiichiro Suzuki, Mo Li, +30

Nature Communications

Systems PharmacologyTranslational MedicineEngineeringHematologyFanconi Anemia Pathogenesis +3

Highly efficient transient gene expression and gene targeting in primate embryonic stem cells with helper-dependent adenoviral vectors

Keiichiro Suzuki, Kaoru Mitsui, Emi Aizawa, +7

Proceedings of the National Academy of Sciences

GSDME-Dependent Incomplete Pyroptosis Permits Selective IL-1α Release under Caspase-1 Inhibition

Emi Aizawa, Tadayoshi Karasawa, Sachiko Watanabe, +9

iScience

Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction

Keiichiro Suzuki, Mako Yamamoto, Reyna Hernández‐Benítez, +24

Cell Research

Genetic DiseasesIn Vivo Gene TherapyNatural SciencesGeneticsGenetic Engineering +9